The goal of our laboratory efforts is to couple understanding of the basic biology of head and neck squamous cell carcinomas (HNSCCs) with translational findings to ultimately transform how we take care of affected patients.
We study the basic immunobiology of the anti-tumor immune response, pathways impacted by targeted therapeutics and correlative clinical responses in HNSCC patients.
We utilize (1) preclinical HNSCC model systems, (2) patient derived samples and xenografts and (3) novel clinical trial designs that together advance our understanding of HNSCCs.